Possible treatment for Charcot-Marie-Tooth disease (CMT1A) discovered

(mpi/umg) Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuropathy and affects more than two million people worldwide. Alone in Germany, at least 30.000 people suffer from Charcot-Marie-Tooth neuropathy which belongs to the class of rare disease. In a close collaboration at the Göttingen campus, researchers at the Max-Planck-Institute for Experimental Medicine and the University Medical Center of Göttingen now hope to use lecithin, a harmless dietary supple-ment to treat the incurable illness. The results of the study were published in „Nature Communications“.

Due to a genetic defect that causes a duplication of the PMP22 gene, patients with a Charcot-Marie-Tooth disease develop a slowly progressive impairment of their peripheral nerves (CMT1A). Early symptoms, like walking difficulties or deformed feet can already occur during childhood. Later, muscle muscle weekness in legs and arms occur, but also numbness, prickling or pain. In rare cases, patients may be forced to use wheelchairs.

The axons, projections of nerve cells in the peripheral nervous system, are sur-rounded by supporting cells over their entire length. These Schwann cells produce a fatty layer, the myelin, around the axons which allows for a faster transfer of electric signals. Using a transgenic rat model of CMT1A, scientists at the Max-Planck-Institute for Experimental Medicine and the University Medical Center in Göttingen, as well as neuroscientists from Leipzig, Würzburg, Heidelberg and Aachen now discovered that diseased Schwann cells show a decreased fat metabolism during their development which causes the impaired myelination. “The production of myelin is extremely laborious for Schwann cells. A disruption, like the one the Charcot-Marie-Tooth disease causes, leaves the nerve fibers without myelin, which limits their functionality”, explains the first author of the study, Robert Fledrich, Max-Planck-Institute of Experimental Medicine and Institute of Anatomy of Leipzig University Medicine.

Schwann cells use Phospholipids for the myelination
Using lecithin, the reduced fat production of Schwann cells may be circumvented and the disturbed myelination in Charcot-Marie-Tooth disease thus be improved. Lecithin is produced from soy or yolk and consists of phospholipids. It is a harmless dietary supplement and the main ingredient of myelin. Initially, the scientists were able to show that the phospholipids in genetically modified rats were absorbed by the Schwann cells and used for the production of myelin.

Therapy studies with diseased rats that were given lecithin in various doses not only showed that a treatment with phospholipids promotes the myelination. “It significantly eases the course of the disease regardless of the start of the therapy”, explains Ruth Stassart, a neuropathologist from the Departement of Neuropathology of Leipzig University Medicine and Max-Planck Institute for Experi-mental Medicine, who co-lead the study. “The promising data from the animal testing and especially the already proven compatibility of with humans, promote Lecithin as a therapeutic agent for the Charcot-Marie-Tooth disease as well as possibly for similar demyelinating diseases”, adds Michael Sereda, a neurologist at the Department of Clinical Neurophysiology at the University Medical Center Göt-tingen and group leader at the Max-Planck-Institute for Experimental Medicine who co-directed the study together with Ruth Stassart.

The participating neurologists and neuroscientists now plan to use these findings from animal models in order to help patients by initiating clinical trials.

contact for scientific information:
Prof. Dr. med. Michael W. Sereda
Max-Planck-Institute of Experimental Medicine
Research Group “Molecular and Translational Neurology”
Department of Neurogenetics
Hermann-Rein-Str. 3, 37075 Göttingen

University Medical Center Göttingen – University of Göttingen
Department of Clinical Neurophysiology
Robert-Koch-Str. 40, 37075 Göttingen
Phone: +49-551-3899-760/732 oder +49-551-39-9662
Email: sereda@em.mpg.de
www.cmt-net.de, www.neurologie.uni-goettingen.de, www.em.mpg.de

Dr. rer. nat. Robert Fledrich
Institute of Anatomy – Leipzig University Medicine
Liebigstr, 13, 04103 Leipzig

Max-Planck-Institute of Experimental Medicine
Department of Neurogenetics
Hermann-Rein-Str. 3, 37075 Göttingen
Phone: +49-341-9715037
Email: fledrich@em.mpg.de

Dr. med. Ruth M. Stassart
Max-Planck-Institute of Experimental Medicine
Research Group “Remyelination and Nerve Repair”
Department of Neurogenetics
Hermann-Rein-Str. 3, 37075 Göttingen

Abteilung für Neuropathologie, Department für Diagnostik
Leipzig University Medicine
Liebigstr. 26, 04103 Leipzig
Email: stassart@em.mpg.de

Prof. Klaus-Armin Nave, PhD
Max-Planck-Institute of Experimental Medicine
Department of Neurogenetics
Hermann-Rein-Str. 3, 37075 Göttingen
Email: nave@em.mpg.de
Phone: +49-551-3899-760

original publication:
„Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy“, R. Fledrich, T. Abdelaal, L. Rasch, V. Bansal, V. Schütza, B. Brügger, C. Lüchtenborg, T. Prukop, J. Stenzel, R.U. Rahman, D. Hermes, D. E-wers, W. Möbius, T. Ruhwedel, I. Katona, J. Weis, D. Klein, R. Martini, W. Brück, W.C. Müller, S. Bonn, I. Bechmann, K.A. Nave, R.M. Stassart & M.W. Sereda; Nature Communications; 2. August 2018 (DOI: 10.1038/s41467-018-05420-0)

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