At the conference, the scientific results of the Genome Research Network will be presented in an international context. Leading scientists with proven expertise in the field of researching neuropsychiatric/neurodegenerative diseases will inform about the following topics:
• Special Lecture: Evolution
• Unipolar Depression
• Bipolar Disorder
• Cognition / Neurodegeneration
• Translating Genotype into Phenotype
• Biostatistics / Computational Genomics
• New Technologies
• Genetic Imaging
• Functional / Animal Studies
The Leopoldina Symposium addresses itself to all scientists and clinicians being interested. The number of participants is restricted to 250.
Neuropsychiatric disorders are among the main causes of impairment due to diseases worldwide. Their course most predominantly is chronic or recurrent and connected with increased mortality. Within the BMBF funded framework of the initiative „National Genome Research Network NGFNplus“, MooDS with its 13 scientific subprojects aims to investigate the causal factors systematically. „MooDS“ is an acronym deriving from the English title of the research network: „Systematic Investigation of the Molecular Causes of Major Mood Disorders and Schizophrenia“.
MooDS is focused on genetic examinations in order to identify the respective genes systematically on a molecular basis. To this end, genomewide association studies are performed in big collectives of patients. Novel statistical procedures are developed and applied to evaluate the genomewide association data. By means of bioinformatic procedures, information on biological relations is implied into the analysis and the validity of examinations is improved. A comprehensive database is compiling detailed disease-related data of a large number of patients. Thus, the significance of disease-associated genes for the clinical manifestation, etiopathology, drug response and long-term prognosis shall be examined.
Based on these genetic findings, the pathophysiology of the scrutinized diseases is to be clarified systematically. On the experimental level, interacting partners of the genes involved are identified and implications on gene expression are verified. Animal models and systembiological approaches allow to illuminate functions in detail. The significance of disease-related genes for brain morphology and function is investigated by brain imaging.
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE)
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