IVAM Product Market „High-tech for Medical Devices“ at COMPAMED 2017

With a number of 53 international exhibitors, the Product Market „High-tech for Medical Devices“, initiated by the IVAM Microtechnology Network, is the largest joint pavilion at COMPAMED – and fully booked. The exhibitors come from Germany, Switzerland, France, the USA, the Netherlands, Austria, Great Britain, Greece and Spain. The IVAM area is located in hall 8a and showcases various solutions for medical technology – all in 700sqm of space. The key technologies to these solutions are microtechnology, nanotechnology, photonics, MEMS and advanced materials.

This year, the international companies and research institutes present miniaturized components and high-tech microelectronics, smart sensors for digitalization, solutions for systems integration, ultra-precise tool-making and functional coatings as well as measuring and screening processes that constantly make medical technology products smarter, safer, cheaper and more reliable.

Additionally, the COMPAMED HIGH-TECH Forum, organized by IVAM, offers insight into research and development of the exhibited processes and products, explains technology trends and provides information on relevant foreign markets. This year, for instance a France session will take place. The COMPAMED HIGH-TECH Forum offers international presentations on all trade show days in hall 8a, booth G40.

Sensor technologies for diagnostics, monitoring and therapy

ams is a global leader in the design and manufacture of advanced sensor solutions. The CMOS Imaging Sensors presented by ams Sensors Germany GmbH feature global and rolling shutter, low noise, high dynamic range and high frame rates through high-speed on-chip ADC and digital interfaces. ams‘ image sensors serve a broad range of applications for medical technology and other markets. The ams portfolio also includes miniature camera modules for endoscopy-like applications, namely the award winning NanEye displaying at the COMPAMED show.

CiS Forschungsinstitut für Mikrosensorik GmbH develops technologies for customized optoelectronic, piezoresistive and impedimetric sensors. Among the novelties are optical sensors for continuous monitoring of the blood pressure without a cuff. The sensor uses methods of pulse wave analysis in a photoplethysmogram and is manufactured on the MORES technology platform of the research institute. Blood pressure data will be determined based on a patented mathematical algorithm. Also presented the first time at COMPAMED are piezoresistive MEMS pressure transducers, which can be used in invasive clinical sensors.

As a leading manufacturer of physical, chemical and biological sensors, Innovative Sensor Technology IST AG presents its sensor portfolio, consisting of thin and thick film platinum and nickel RTD temperature sensors, thermal mass flow sensors, capacitive humidity sensors, humidity modules, conductivity sensors and biosensors. These sensors are characterized by their accuracy and consistency in various measurement conditions. They are applied in measuring instruments for medical and various other applications.

In biosensors, enzymes are enabling the specific measurement of particular substances even in complex mixtures like whole blood. Cost-effective manufacture and factory-calibration enable single-use applications with highest application reliability. By using Jobst Technologies GmbH‘s flow-through biosensor chips, glucose and lactate can either be analyzed with a rate of 48 samples per hour in analyzers, or be monitored simultaneously like in the first continuous glucose & lactate monitor for critically ill patients (EIRUS, Getinge).

Sensirion AG, expert for safe and reliable medical applications, is presenting its innovative sensors for the measurement and control of gas and liquid flows, differential pressure, humidity, temperature and gas (VOC) at COMPAMED. This year’s product highlights are a new liquid flow sensor for the measurement of ultra-low flow rates in drug delivery applications (infusion) and single-use and autoclavable flow sensors for proximal flow measurements in ventilation and anesthesia. Both sensors are available as versions for neonatal and pediatric applications.

Silicon Microstructures (SMI), Inc.’s Cobra product line is the first commercially-available pressure sensor with attached cable that fits into 1-French devices. The sensors are small (220 microns wide), stable (drift in 37C saline <1mmHg per hour) and smart (a temperature-compensated, digital or amplified analog version is available). The presentation at COMPAMED will demonstrate how this sensor assembly can simplify or provide risk reduction in urodynamics, endourology, cardiology, emergency surgery, intracranial pressure monitoring and other procedures.

Surface solutions, advanced materials and implants

At COMPAMED 2017 Coatema Coating Machinery GmbH will present the New Easycoater, an extraordinarily precise sheet-to-sheet lab coating and printing line used for high-precision coating and printing of sheet substrates. In addition, Coatema introduces the Nanoimprint coating line for highly innovative roll-to-roll manufacturing of micro- and nanostructured surfaces as they are often used in latest biomedical sensors.

Surfix BV presents its state-of-the-art surface coatings for the micro- and nanotechnology market. The material-selective and local surface modification offers accurate and precise control of surface properties. With multiple functionalities like hydrophobic, hydrophilic, anti-biofouling and biofunctionalization on various inorganic and polymeric surfaces and even inside microfluidic channels, Surfix helps to exploit the full potential of its clients’ devices.

SCS – Specialty Coating Systems will be exhibiting Parylene conformal coating services at COMPAMED. SCS Parylene coatings are biocompatible, biostable and offer excellent moisture, chemical and dielectric barrier properties to many medical devices, including stents, catheters, pacemakers, needles and mandrels, and to pharmaceutical containers and applications as well. Ultra-thin and perfectly conformal, Parylene coatings are ideal for advancing medical technologies.

Many medical applications are using the advantage of micro- and nanostructured surfaces. temicon GmbH offers the complete technology range needed for the processing and the serial production of functional surfaces by injection molding or roll imprint. Typical products are nebulizer nozzles with micrometer holes for the generation of aerosols, microstructured titerplates for stem cells differentiation, conic micromembranes for filtering of cells, or anti-bacterial surfaces. In addition, temicon offers injection mold inserts and injection molding service for the production of micro- or nanostructured polymer parts.

Individually adapted implants, which are completely integrated into the body and, in the long term, are replaced by the own bone substance: this is made possible by a new hybrid shaping technique developed at Fraunhofer Institute for Ceramic Technologies and Systems IKTS. The patient-specific, hard bone shell comes out of the 3D printer. The spongy inner structure is simulated by a ceramic freeze foam, which is proven to support cell growth and is pressure-resistant and bioactive, too.

Following the vision of taking implantable technologies to the next level CorTec GmbH provides innovative solutions that enable highly efficient personalized therapies. Based on their flexible technologies they offer individualized components of active implants such as electrodes or hermetic encapsulations. CorTec is located in Freiburg, Germany and will soon move to a new facility with its own cleanroom production site.

Precise microfluidic systems for analytical instrumentation

HNP Mikrosysteme GmbH produces micro annular gear pumps. These pumps are ideally used where fast and highly precise dosage is required. Five series guarantee a flow rate from 1 µl/h to 1152 ml/min. mzr-pumps are characterized by low pulse delivery, minimal dead volume, long service life, small dimensions, powerful materials and ease of maintenance. HNPM offers development of OEM pumps, comprehensive application-specific consulting and technical support. Application possibilities are, amongst others, in the field of life science and analytical instrumentation.

Having built up experience working on thousands of R&D as well as large-scale projects, microLIQUID S.L. has developed a unique combination of skills including microfluidic design, nano- and microfabrication, polymer sciences and automated assembly, all of which have been set to work in mass production facilities. microLIQUID also develops and manufactures fully automated analyzer systems and drug delivery equipment focused on diagnostic and pharmaceutical markets.

Micronit GmbH is a key supplier of microfluidic devices to life sciences and chemistry markets worldwide and has been manufacturing microfluidic components for more than 15 years. These products are used in DNA analysis, as medical tests, as components for analytical instrumentation and space technology. Micronit has extensive experience in micromachining, microfluidics and MEMS and is a dedicated research and development partner for both science and industry.

Lab-on-a-chip (LOC) systems are microfluidic systems equipped with electro-chemical micro pumps, bio sensors and partly heating devices and controlled by miniaturized electronics. Up to 15 pumps and 4 heating components work on one cartridge. In addition to LOC the Fraunhofer Institute for Electronic Nano Systems ENAS will exhibit two-axes acceleration sensors for integration in implants that are fabricated in BDRIE technology with a complete size of 1.2 x 1.5 mm². They will also present the project Sens-o-Spheres, where a system for wireless inductive charging of spheres for bioreactors was developed.
Microelectronic components and systems

Development and production services for new product integration or re-design for medical devices from class 1 to class 3 are the major expertise of AEMtec GmbH. AEMtec provides a wide range of assembly and packaging technologies in cleanroom environment (Wafer Back-End Services, CoB, Flip Chip, SMT) and Box Built. Through longstanding experience AEMtec has positioned itself as a reliable partner for the manufacture of products with a high level of integrity and reliability. AEMtec is ISO 13485 certified.

The colorPol polarizers displayed by CODIXX AG are characterized by a high transmission up to 99%, an exceptional contrast ratio of more than 105:1, resistance against UV-radiation and most chemicals, operating temperatures from -50 to +400 °C, and durable glass; still they are as thin as foil polarizers. This makes colorPol perfect for every use, whether as a single part in laboratories or a serial component for any application in life sciences. The polarizers are made according to customer wishes in different sizes, shapes, thicknesses and quantity in the required wavelength range.

European Sensor Systems specializes in the development of silicon-based modules utilizing micro-electronic technologies. Its prime scope of work is to design, develop and produce customer-specific MEMS modules via standard industrial processes employed for medical, industrial and aerospace applications. ESS’s MEMS-based products are flow systems for gases including oxygen, silicon capacitive pressure sensors for gases and liquids underpinned by ESS’s innovative microfabrication process, capacitive accelerometers and signal conditioning electronics.

Exceet electronics GmbH is an experienced specialist for industrialized and automated development and manufacturing of high-quality and complex electronic modules, components and systems. In medical technology for example, they adopt the overall responsibility for the development and manufacturing of medical devices and support their admission. Exceet electronics is a wholly reliable outsourcing partner and general contractor, which is developing, producing and assembling MedTec devices according ISO 13485.

Fraunhofer Institute for Silicon Technology ISIT develops and manufactures components and systems for microelectronics and microsystem technology. At COMPAMED 2017 Fraunhofer ISIT will present mobile multiparameter analysis systems for point-of-care diagnostics and new developments for sports, medical, safety and automotive applications. Examples are self-sufficient force sensor shoe inserts for acoustic gait analysis or hybrid electronics systems for physical movement monitoring.

The activity portfolio of ILFA Industrieelektronik und Leiterplattenfertigung aller Art GmbH comprises all services starting from CAD, manufacturing prototypes up to middle series volumes of 1 to over 32 layers standard rigid, flex or rigid-flex PCB´s. The portfolio includes HDI- and microfine PCBs as well as high frequency materials, embedded solutions and fluid channels.

Magic Power Technology group is a leading manufacturer of switch mode power supplies with more than 20 years of experience. In addition to a wide range of standard products, the group specializes in customized OEM power supplies. On display will be products from 30W single output up to 1,3kW modular medical power supply. The focus of Magic Power Technology is to deliver products with a long lifetime and high efficiency. Magic Power Technology GmbH in Germany has in-house EMC test and Electronic laboratory facilities to enable them to offer a perfect technical and commercial service both pre and post sales.

Microdul AG specializes in high-quality microelectronics. The company’s three business lines are customized modules, thick-film and mixed-signal low-power ASICs. With ISO 13485, the company’s core competence is in producing cutting-edge micro miniature modules for medical and industrial applications, such as implants, hearing aids and other applications in healthcare.

Optiprint AG offers consultation, development and manufacture at its production facility in east Switzerland. Optiprint guarantees Swiss quality and precision. The company offers innovative PCB solutions like high-frequency printed circuit boards, metal-core printed circuit boards, flexible and flex-rigid printed circuit boards, ultra-fine lines and printed circuit boards with ticer foil.

SMT ELEKTRONIK GmbH is an expert for development, production and full service of electronic assemblies and devices. In order to guarantee the best possible quality and optimal production processes, the company has developed a unique method: the EMS-Preflight method makes the development and production of product electronics inimitably series-reliable. SMT ELEKTRONIK works in series from the very beginning, starting with design and continuing through series production to a reliable service.

Turck duotec GmbH develops and produces miniaturized electronic components such as LED lighting on ceramic substrates and overmolded sensor modules. By using the autoclavable overmolding technology, electronic components are effectively protected from the effects of hot steam sterilization in an autoclave at 134 ° C and 2 bar water vapor pressure. The autoclavable overmolding technology allows precise and miniaturized packaging of sensors and other electronic assemblies using overmolding with plastics materials and thus permitting repeated applications for medical usages.

Printed circuit boards “made in Switzerland” are very much in demand in the highly sensitive application area of medical devices. Varioprint AG manufactures high-precision printed circuit boards for a wide range of applications, such as heart pace makers, neurostimulation, hearing aids, implantable analysis devices or dental tools. From diagnostic devices to implantable systems, the name Varioprint is synonymous with uncompromising printed circuit board quality.

Laser technology for medical manufacturing

With nearly 440 employees and more than 19,500 m² net floor space the Fraunhofer Institute for Laser Technology ILT is one of the most important development and contract research institutes in its specific field. The activities cover a wide range of areas such as the development of new laser beam sources and components, precise laser-based metrology, testing technology and industrial laser processes. This includes laser cutting, caving, drilling, welding and soldering as well as surface treatment, micro processing and rapid manufacturing.

Micreon GmbH is one of the world’s most prestigious contract manufacturers and technology consultants for micromachining with ultrafast lasers. Ultrafast laser technology has all the advantages necessary for current and future miniaturization applications, with processing resolutions in the sub-micrometer range that are not only smaller, but of higher quality than comparable conventional methods. Micreon is partner for contract manufacturing, research and consulting.

ROFIN-BAASEL Lasertech GmbH & Co. KG offers laser solutions for medical technology, including the StarCut tube family, the high-precision laser cutting systems for tubes and medical implants. In addition, the company presents laser processing systems for high-precision welding, cutting, structuring, drilling and marking.

Multiphoton Optics GmbH offers a high-precision 3D printing platform (LithoProf3D®) and software (LithoSoft3D®) for the additive and subtractive fabrication of arbitrarily shaped structures in the volume or on the surface of materials. This technology supports a high-precision fabrication of 3D optical interconnects, aspheric or free-form micro optics, biomedical products, such as scaffolds for tissue engineering, microfluidic cells, or drug delivery structures. For this, the company supports its customers with prototyping & engineering services (LithoP&E).

Optical systems and components

The Berliner Glas group is one of the world’s leading providers of optical key components, assemblies and systems as well as high-quality refined technical glass and optical bonded touch systems. Berliner Glas develops, produces and integrates optics, mechanics and electronics into innovative system solutions for its customers. As a classic OEM partner, Berliner Glas supplies innovative companies from the medical technology and life science market who are a cut above the competition thanks to the quality and functionality of their products.

The customizable micro camera FISBA FISCam with high resolution and extremely small diameter is suitable for a wide variety of customized applications in life sciences and industry. Thanks to the combination of the extremely small dimensions and the high resolution, it is possible to make invisible niches visible. FISBA AG strives to be the partner with whom clients collaborate to reach the best solution and design for their system. The modern, high-tech and unique production facilities enable FISBA to manufacture prototypes as well as individual items or large series.

IMT Masken und Teilungen AG presents cost-effective glass components for biophotonics and medical applications. IMT develops and produces large volumes of consumables, custom-made microfluidic devices, optical components and sensors in glass and quartz. IMT’s capabilities include structured metallic and dielectric coatings, etching of channels and nanopatterns, integration of on-chip electrodes, waveguides, optical filters and biocompatible materials for applications such as sequencing, lab-on-a-chip, organ-on-a-chip, single cell detection & analysis or HTS.

Mikrop AG is the leading source for Swiss precision miniature optics serving all high-tech markets. For 35 years the company has developed, manufactured and mounted highly complex, miniaturized optical components and sub-assemblies. Today Mikrop is one of only a few companies worldwide who are able to manufacture serial high-precision lenses in reliable top quality and starting at diameters of just 0.3mm and up to 15mm.

SwissOptic AG, a company of the Berliner Glas Group, is one of the world’s leading providers of optical key components, assemblies and systems. From concept to volume production, SwissOptic offers complete solutions for medical technology applications, all from one source. Their know-how ranges from feasibility tests for customer-specific requirements to planning, advising, procurement and prototype production all the way to reliable volume production. SwissOptic focuses on the areas of ophthalmology and life sciences.

Volpi AG develops, industrializes and manufactures optoelectronic module solutions for in vitro diagnostics and life science research (fluorescence, reflectometry, chemiluminescence, calorimetry, spectroscopy). Applications include modules for PCR, next-generation sequencing, immunoassay systems and clinical chemistry analyzers. Based in the USA and Switzerland and certified ISO 13485, Volpi provides comprehensive systems engineering combined with lean manufacturing throughout the product life cycle.

As a partner in medical technology zünd precision optics develops and manufactures high-quality planar optical components and systems from 0.2 mm up to 50 mm in various shapes. Their added value includes grinding, lapping, polishing, coating, varnishing and curing of optical glasses, quartz and glass ceramics. The company supports clients in the development of components and assemblies with the highest precision and cleanliness requirements from the prototype till the serial production.

Miniaturized components and systems for medical devices and manufacturing

BEUTTER Präzisions-Komponenten GmbH & Co.KG is specialist for fine-mechanical components of high manufacturing depth in small series and supplies all areas of medical technology. Beutter builds individual parts and assemblies for technical instruments in medicine, prostheses and implants up to risk class III. The company employs all machining technologies at its site and appoints certified suppliers for special processes. Beutter assists its clients in development and documentation and is certified in accordance with ISO 13485:2016.

CG.TEC Injection is a leading expert in high-precision injection-molding and manufactures miniature parts and microcomponents out of polymers. The company designs parts for manufacture, develops precision tooling and automates the production. The scope of products ranges from small equipment to disposables for different applications: diagnostics, dentistry, surgery, microfluidics, and many more.

Electromag SA is specialized in the design, production and sale of high-performance miniature brushless motors for the medical industry. The company has developed a significant experience in the field of medical respirators as well as for other medical devices that require high-speed, low noise and reliable motors. Electromag is ISO9001 and ISO13485 certified.

The Austrian branch of Microsystems UK Ltd is specialist in medical, biotech and optical micro-molding solutions including molds, plastic parts and complete systems for drug delivery, medical diagnostics, surgery and inhalation. Further capabilities include ultra-precision multi-cavity molds and nano-structuring, manufactured in high and medium quantities to suit the customers’ specific requirements.

The benefits of using RFID technology in the medical and healthcare sector are immense: huge time savings, cost reduction through optimized processes and improvements in quality management are just some of them. Microsensys GmbH offers established RFID system solutions for applications such as unique part tagging, specimen management, inventory, pressure and temperature monitoring as well as special security solutions. At COMPAMED microsensys shows an RFID sensor system solution for continuous temperature monitoring during steam sterilization at +136 °C and 2 bar.

PI (Physik Instrumente GmbH & Co.KG) is a leading manufacturer of nano and micropositioning systems. PI can rely on a broad range of drive solutions for applications in research, diagnostics and therapy. This means that endoscopy, for example, can benefit from piezo-motorized and magnetic miniature drives. In addition, PI offers piezoceramic elements that can be used in sensory and actuator applications, for example, in flow meters or as components in pump and metering technology. PI products therefore meet the high requirements on reliability and lifetime.

At COMPAMED RKT Rodinger Kunststoff-Technik GmbH presents itself as a partner for precision mold making, precision injection molding, 2 and 3 shot components, micro parts, microfluidic parts, part assembly, cleanroom production, mold engineering, and validation.
Research, development and manufacturing services

CSEM Centre Suisse d’Electronique et de Microtechnique SA is a Swiss privately owned non-profit R&D company. Around 450 employees are working for the organization and generate a turnover of 80 Mio CHF. CSEM is realizing the transfer of micro and nano technologies to the industry in Switzerland, Europe and worldwide. CSEM’s technology solutions foster innovations and are applied in broad market areas. CSEM covers the complete process chain of complex micro systems: from design to manufacturing and system integration. CSEM has been certified to ISO 9001. The CSEM systems division has been certified to ISO 13485 Medical Devices QMS since 2014.

For more than 15 years the Fraunhofer Institute for Reliability and Microintegration IZM has served the medical industry as a one-stop-shop solution provider with its technology portfolio adapted to heart pace makers, to retinal implants, to lab-on-chip platforms, to neuroprosthetic devices and hearing aids. Services include electronic packaging and reliability assessments for miniaturized medical devices and implants, lab-on-substrate technologies for POCT, and improved functionalities for neuronal interfaces and intelligent prostheses.

Hahn-Schickard stands for client- and industry-oriented, application-driven research, development, and production with microsystems engineering. At COMPAMED 2017, Hahn-Schickard will show, among other things: an ultra-precision tool insert for the production of a microlens array; high-precision microfluidic tools and injection-molded microfluidic systems; printed electrochemical sensors; ultra-light flexible microsystems based on films; Rapid Prototyping of MID by additive manufacturing and laser soldering; a novel injection device for intradermal administration of drugs.

In the Healthcare & Industry division Jenoptik develops specific system and application solutions with customers worldwide in the healthcare sector and industry. The product portfolio includes semiconductor chips, optoelectronics, laser technology, polymer optics, electronics and software. Based on its core competences from laser and LED based beam sources, optical components and modules to sensors, digital imaging and system integration, Jenoptik is a leader in the development of OEM system solutions and products for the life science industry.

Statice has provided contract R&D and contract manufacturing of advanced medical devices for almost 40 years. Examples presented at COMPAMED include: short-term and long-term implants made of silicone or polymers; specific catheters, endoscopes, ancillaries and electro-medical devices for laboratories and doctors surgery; electrospun patches or tubes for wound surgery; drug delivery with controlled release of drugs.

Efficient networks for initial business contact

IVAM Microtechnology Network is an international association with members in the fields of microtechnology, nanotechnology, advanced materials and photonics. IVAM supports mainly small and medium-sized companies in bringing innovative technologies and products to market and thus securing advantages in international competition. Since 1995 IVAM has been supporting companies and institutions from all around the world. The central mission of the association is to create synergies and to support its members in exchanging knowledge, initiating joint projects and networking with each other and potential customers.

In the BMWi-funded network project ToGeTher, small and medium-sized companies have joined forces to develop marketable medical technology products in trustful cooperation. ToGeTher connects SMEs with research organizations and with healthcare providers. With more than 100 players from industry, research and healthcare ToGeTher addresses the flourishing markets „Wearables“ and „Point-of-Care-Diagnostics“. In particular, new technologies are to be used as they are made available, for example, by TOLAE. TOLAE (Thin, Organic and Large Area Electronics) comprises electronic solutions that enable flexible or even stretchable applications and can be manufactured in a cost-effective manner, for example in a roll-to-roll process. The network is constantly being expanded in order to be able to carry out projects comprehensively and competently.

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