Jena. In growing age, neurodegenerative diseases occur more frequently, causing immense costs for long-lasting treatments or special care. Regarding our aging population, this is a problem that is enormously important not only for patients and their families, but also for society.
The Morrison Research Group at the Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) was able to identify Cytokines in several projects that are likely to play a central role in peripheral nerve aging. To investigate connections between various factors circulation in the bloodstream and nerve aging more in detail, as well as carry out experiments with nerve and non-nerve cells, they submitted their project idea to participate in the international competition “ImmunoTools Award 2018” of the company ImmunoTools.
The Award Winners
„We are really happy to receive this award and that our project idea has been selected“, says Dario-Lucas Helbing. Together with his colleague Leopold Böhm, he recently started the Master’s program „Molecular Medicine“ for highly motivated medical students at the Friedrich Schiller University in Jena, which not only offers them the opportunity to do their doctorate, but also improves their position in scientific competition. With the provided ImmunoTools products both medical students will now concentrate on the aging nervous system and investigate the interaction of cells in the nervous system and consequences of maladjustments in cellular communication during aging more closely.
The Project
„We already know that in aging nerves chronic inflammations can occur, which impair nerve regeneration“, explains Leopold Böhm. This phenomenon is already known from other organs as “InflammAging”. “To better understand this process, our research group investigates the network of cytokines between glial cells, neurons and the immune system in old mice in detail. Our vision is to use our knowledge to block potentially disruptive cytokines, thus combating disorders of the nervous system in older people.”
With their research approach, they follow up a recent study of the Morrison Group published in the journal Aging Cell. Here the researchers investigated regeneration and maintenance of peripheral nerves during aging. They were able to show that nerve regeneration is impaired in old age and that more macrophages, so-called inflammatory cells, are increasingly stored, which lead to a permanent inflammation.
During this latent inflammatory process, more proinflammatory cytokines are released, which lead to chronic diseases in older people. They were able to identify two Cytokines, which were upregulated in old nerves and play a crucial role in inflammation: CCL 2 and CCL 11. This is an indication that the newly found cytokines are associated with aging and regeneration processes.
“This award enables us to investigate the communication of different cells of the nervous system during aging,” say both awarded MD students. With the “prize” in the form of provided reagents, the young researchers can investigate, which cytokines have an influence on the ability of nerve cells to regenerate and to maintain. Their overall goal is to improve nerve regeneration in old age.
Complementary Publication
Inflammaging impairs peripheral nerve maintenance and regeneration. Büttner R, Schulz A, Reuter M, Akula AK, Mindos T, Carlstedt A, Riecken LB, Baader SL, Bauer R, Morrison H. Aging Cell 2018, e12833. doi: 10.1111/acel.12833.
IDW
http://idw-online.de/en/news704343
Contact
Dr. Kerstin Wagner
Press and Public Relations
Phone: 03641-656378, Email: presse@leibniz-fli.de
++++++++
Background information
The Leibniz Institute on Aging – Fritz Lipmann Institute (FLI) – upon its inauguration in 2004 – was the first German research organization dedicated to research on the process of aging. More than 330 employees from over 30 nations explore the molecular mechanisms underlying aging processes and age-associated diseases. For more information, please visit
The Leibniz Association connects 93 independent research institutions that range in focus from the natural, engineering and environmental sciences via economics, spatial and social sciences to the humanities. Leibniz Institutes address issues of social, economic and ecological relevance. They conduct knowledge-driven and applied basic research, maintain scientific infrastructure and provide research-based services. The Leibniz Association identifies focus areas for knowledge transfer to policy-makers, academia, business and the public. Leibniz Institutes collaborate intensively with universities – in the form of “WissenschaftsCampi” (thematic partnerships between university and non-university research institutes), for example – as well as with industry and other partners at home and abroad. They are subject to an independent evaluation procedure that is unparalleled in its transparency. Due to the institutes’ importance for the country as a whole, they are funded jointly by the Federation and the Länder, employing some 19,100 individuals, including 9,900 researchers. The entire budget of all the institutes is approximately 1.9 billion EUR. See
contact for scientific information:
Dr. Kerstin Wagner (FLI)
original publication:
Inflammaging impairs peripheral nerve maintenance and regeneration. Büttner R, Schulz A, Reuter M, Akula AK, Mindos T, Carlstedt A, Riecken LB, Baader SL, Bauer R, Morrison H. Aging Cell 2018, e12833. doi: 10.1111/acel.12833.